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Neuroticism is one of the Big Five higher-order personality traits in the study of psychology.

Individuals who score high on neuroticism are more likely than average to be moody and to experience such feelings as anxiety, worry, fear, anger, frustration, envy, jealousy, guilt, depressed mood, and loneliness.

While some statement-based measures of neuroticism have similarly acceptable psychometric properties in North American populations to lexical measures, their generally emic development makes them less suited to use in other populations.

Although they are low in negative emotion, they are not necessarily high on positive emotion.

People who are neurotic respond worse to stressors and are more likely to interpret ordinary situations as threatening and minor frustrations as hopelessly difficult.

They are often self-conscious and shy, and they may have trouble controlling urges and delaying gratification.

People with high neuroticism indexes are at risk for the development and onset of common mental disorders, Galen of Pergamom popularized the idea that mixes of four bodily fluids or humours resulted in four personality types or temperaments.